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Next-Generation Sequencing (NGS) is a revolutionary DNA sequencing technology that enables fast, high-throughput, and cost-effective genome and transcriptome sequencing. Unlike earlier techniques, NGS can sequence millions of DNA strands simultaneously, transforming large-scale genomic studies and precision medicine. 

NGS has revolutionized oncology, enabling major breakthroughs in cancer diagnosis and treatment. By sequencing tumor DNA and RNA, oncologists can detect genetic mutations driving tumor growth and recommend targeted treatment options based on the patient’s unique genetic alterations. Liquid biopsies provide a non-invasive way to monitor tumor changes over time and in response to treatment using NGS. 

How NGS Sequencing Has Transformed Cancer Testing 

NGS sequencing has transformed precision cancer testing by assessing multiple genes in a single assay, eliminating the need for multiple tests. This comprehensive approach provides a complete picture of a tumor’s molecular profile, allowing doctors to develop customized treatment plans tailored to each patient’s unique genetic profile. 

NGS also enables continual re-sequencing of tumor samples to monitor cancer evolution over time and adapt treatment. Some clinics now offer serial sequencing services, re-sequencing tumor samples at multiple points during treatment to monitor tumor evolution in real time. 

While NGS sequencing has made precision medicine a reality for many cancer patients, it’s not without challenges. Interpreting the vast amounts of data can be difficult, and determining which mutations are driving the cancer versus just “passenger” mutations requires significant expertise. 

However, NGS has been a game changer for cancer care. By enabling a precision medicine approach, it has given new hope to patients who previously had few or no treatment options left. As our knowledge and treatment capabilities continue to expand, NGS will only become more transformative. 

The Future of NGS Testing for Cancer Patients in Vietnam 

In Vietnam, NGS sequencing has been instrumental in enabling precision oncology. As NGS testing becomes more affordable and accessible, cancer patients across Vietnam will benefit from targeted therapies matched to their tumor’s genomic profile. With more genomic data from NGS, drug companies can develop new targeted therapies for previously unknown mutations, giving oncologists in Vietnam access to an expanding array of precision medicines. 

In conclusion, NGS sequencing has completely changed the game when it comes to precision cancer testing. This revolutionary technology is enabling truly personalized medicine, where patients can receive targeted therapies catered to the specific mutations driving their disease. The future is bright when it comes to outsmarting cancer, and NGS will light the way. 

Vela Diagnostics' NGS system is available in Getz Healthcare Vietnam. Please feel free to contact us for more information. 

Sources: 

• https://www.illumina.com/science/technology/next-generation-sequencing.html 
• https://www.illumina.com/science/technology/next-generation-sequencing/beginners.html 
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020069/ 
• https://www.illumina.com/areas-of-interest/cancer/ngs-in-oncology.html 
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777453/ 
• https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00206-7/fulltext 
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719592/ 
• https://ascopubs.org/doi/10.1200/PO.22.00715 
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319859/ 
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792166/ 
• https://www.illumina.com/areas-of-interest/cancer/ngs-in-oncology.html 
• https://ascopubs.org/doi/10.1200/JGO.18.00086